FEATURES OF HEMATOLOGICAL PARAMETERS IN CALR-POSITIVE PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS
نویسندگان
چکیده
منابع مشابه
Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms
Somatic mutations in the CALR gene have been recently identified as acquired alterations in myeloproliferative neoplasms (MPNs). In this study, we evaluated mutation frequencies, laboratory features, and granulocyte activation in Chinese patients with MPNs. A combination of qualitative allele-specific polymerase chain reaction and Sanger sequencing was used to detect three driver mutations (i.e...
متن کاملCorrection: Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms
There are errors in the Funding section. The correct funding information is as follows: This work was supported by National Natural Science Fund (NO. 81241014), Shanxi Natural Science Fund (NO. 2011011038–2), The Science and Technology Innovation Fund of Shanxi Medical University (NO. 01201413), The Younger Fund of the Second Hospital of Shanxi Medical University (NO. 20120101), The Graduate ex...
متن کاملCALR mutation characterization in myeloproliferative neoplasms
Identification of somatic frameshift mutations in exon 9 of the calreticulin gene (CALR) in myeloproliferative neoplasms (MPNs) in December of 2013 has been a remarkable finding. It has provided a new molecular diagnostic marker, particularly in essential thrombocythemia (ET) and primary myelofibrosis (PMF), where is the second most common altered gene after JAK2V617F. There are two main types ...
متن کاملSomatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
BACKGROUND Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains a challenge. METHODS We performed exome sequencing of samples obtained from 151 patients with myeloproliferative neoplasms. The mutation status of ...
متن کاملSequential evaluation of CALR mutant burden in patients with myeloproliferative neoplasms
We investigated the variation of CALR-mutant burden during follow-up in 105 CALR-mutant MPN and compared it to the variation of JAK2-mutant burden in 226 JAK2-mutant MPN.The median allele burden at last evaluation was significantly higher than at first evaluation in essential thrombocythemia (ET) (49.5% vs 45%, P < .001) but not in primary myelofibrosis (PMF) (52% vs 51%, P 0.398). Median value...
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ژورنال
عنوان ژورنال: Bulletin of Problems Biology and Medicine
سال: 2018
ISSN: 2077-4214,2523-4110
DOI: 10.29254/2077-4214-2018-1-1-142-227-230